TABLE 5.

Multivariable Survival Analysis of OS

	Overall Survival, mo*
Covariates	Hazard Ratio (95% CI)	HR P	Type3 P†
Resection			<0.001
Yes	0.46 (0.29–0.73)	<0.0001
No	REF	—
Age at diagnosis			<0.001
18–34	0.55 (0.34–0.90)	0.018
35–50	0.62 (0.51–0.76)	<0.001
51+	REF	—
Sex			0.030
Female	0.88 (0.78–0.99)	0.030
Male	REF	—
Year of diagnosis			0.003
2010–2014	0.82 (0.73–0.94)	0.003
2004–2009	REF	—
Histology			<0.001
Carcinoid tumor, NOS	0.67 (0.57–0.78)	<0.001
Atypical carcinoid tumor	1.16 (0.86–1.57)	0.331
Neuroendocrine carcinoma, NOS	REF	—
Primary Site			<0.001
Rectum and colon	1.81 (1.47–2.24)	<0.001
Prostate	2.15 (0.67–6.87)	0.195
Kidney	2.06 (0.84–5.05)	0.115
Lung	1.50 (1.24–1.81)	<0.001
Liver	1.09 (0.60–1.98)	0.777
Gastric and stomach	1.86 (1.34–2.57)	<0.001
Pancreas	1.17 (0.97–1.41)	0.106
Small bowel (ileum, duodenum, jejunum)	REF	—
Surgical margins			0.048
Not available	0.79 (0.48–1.31)	0.366
No	0.73 (0.57–0.94)	0.014
Yes	REF	—
Radiation therapy at any CoC facility			0.001
Not available	0.37 (0.11–1.17)	0.090
Yes	1.33 (1.12–1.58)	0.001
No	REF	—
Chemotherapy at any CoC Facility			<0.001
Not Available	0.83 (0.56–1.22)	0.340
Multi–agent chemotherapy	1.34 (1.15–1.56)	<0.001
Single–agent chemotherapy	1.03 (0.85–1.25)	0.741
Chemotherapy administered, type and number of agents not documented	1.39 (0.99–1.96)	0.057
No	REF	—
Charlson–Deyo Score			<0.001
2+	1.78 (1.44–2.21)	<0.001
1	1.03 (0.88–1.20)	0.692
0	REF	—

Bold values are statistically significant.

^*Number of observations in the original data set = 2361. Number of observations used = 2361.

^†Backward selection with an alpha level of removal of .20 was used. The following variables were removed from the model: Regional Nodes Examined, Regional Nodes Positive, Pathologic Stage Group, Race, Spanish Hispanic Origin, and Urban/Rural 2013.

REF indicates reference