Figure 2.

Effect of STZ, metformin, DM, MHY, and DM+MHY on MWM in rat in different groups

A) escape latency time in 4 blocks in the acquisition phase of spatial memory. (ANOVA Two-way; P<0.0001). B) escape latency time in the probe test of spatial memory in MWM (ANOVA one way, Tukey post hoc). C) total time spent in the target quadrant in probe test of spatial memory in MWM. D) Comparison of swimming speed (velocity) in MWM among groups. E) heat maps showing the representative MWM tracking of groups during retrieval trials, increasing color intensity (arbitrary scale) represents increased time spent. Data are presented as mean±SEM. * P<0.05, **P<0.01, ***P<0.001, ****P<0.0001 (n=8).

STZ: Streptozotocin; DM: Dorsomorphin; MWM: Morris water maze