Fig. 4.
Summary of tra1Q3 phenotypes associated with azole treatment in S. cerevisiae and C. albicans. In S. cerevisiae, compromise of Tra1 function associated with the tra1Q3 allele results in decreased expression of genes associated with azole resistance such as ERG11 and PDR5. Consequently, tra1Q3 cells show increased accumulation of intracellular azole. In C. albicans, tra1Q3 is linked to the increased expression of ERG11 and CDR1, increased efflux of azole, and consequently, increased drug resistance. Created with Biorender.com.