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[Preprint]. 2024 Jan 22:2024.01.18.576328. [Version 1] doi: 10.1101/2024.01.18.576328

Table 2:

Summary of kinase profiling of CX-4945, 1 and 2 tested against CK2α, CK2α’ and GSK3β in the Kinase HotSpot Assay.

Compound ID: Compound IC50 (μM): Fold change: α’ vs α Fold change: α’ vs GSK3β
CK2α CK2 α’ GSK3β
CX-4945 0.0019 ± 0.000011 0.0017 ± 0.00013 0.14 ± 0.013 1.1 82
1 0.97 ± 0.14 0.11 ± 0.00035 8.6 ± 0.68 8.8 78
2 9.1 ± 0.39 1.2 ± 0.026 21 ± 0.44 7.6 17.5