Table 2:
Summary of kinase profiling of CX-4945, 1 and 2 tested against CK2α, CK2α’ and GSK3β in the Kinase HotSpot Assay.
| Compound ID: | Compound IC50 (μM): | Fold change: α’ vs α | Fold change: α’ vs GSK3β | ||
|---|---|---|---|---|---|
| CK2α | CK2 α’ | GSK3β | |||
| CX-4945 | 0.0019 ± 0.000011 | 0.0017 ± 0.00013 | 0.14 ± 0.013 | 1.1 | 82 |
| 1 | 0.97 ± 0.14 | 0.11 ± 0.00035 | 8.6 ± 0.68 | 8.8 | 78 |
| 2 | 9.1 ± 0.39 | 1.2 ± 0.026 | 21 ± 0.44 | 7.6 | 17.5 |