Figure 9:

Overlaps between chromatin sections. A) Schematic plot of the overlap parameter $O(s)$ for active loop extrusion (black), random walks (red), and fractal loopy globules (purple) as a function of genomic length on a log-log scale. The black and purple curves merge for $s\ge N_{e,active}$. The horizontal dashed line indicates the onset of entanglements. We use the volume fraction of chromatin in the nucleus $\varphi =0.15$ and $O_{KN}=10$. B) Chromatin sections within TADs (green circles) overlap and have increased contact probabilities. Neighboring TADs (purple circles) are mostly segregated apart from a narrow interface. C) Inter-TAD fraction of all intra-chromosomal contacts made by loci in a TAD as a function of TAD length. D) Intra-TAD fraction of all intra-chromosomal contacts made by loci in a TAD as a function of TAD length.