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[Preprint]. 2024 Jan 26:2024.01.23.576771. [Version 1] doi: 10.1101/2024.01.23.576771

Figure 3. ZBP1 is overexpressed in the epidermis of autoimmune photosensitive diseases.

Figure 3.

A. Graphical representation of data acquisition from lesional skin microarrays. B. ZBP1 expression in lesional cutaneous lupus (CLE) (n=90) compared to healthy control (CTL) (n=13) (left), by lesion subtype (discoid lupus erythematosus (DLE) or subacute cutaneous lupus erythematosus (SCLE), middle) and based on the presence or absence of systemic lupus via >4 1997 ACR criteria (right). C. Correlation of ZBP1 expression in CLE with IFN score, linear regression. D. ZBP1 expression in childhood onset systemic lupus erythematosus (cSLE, n=7) compared to CTL (n=8). E. Correlation of ZBP1 expression with IFN score in cSLE. F. Violin plots showing ZBP1 expression from scRNA sequencing across cutaneous cell types from nonlesional lupus skin (NLE, n=14), lesional lupus skin (LLE, n=14) compared to CTL (n=14). G. Expression of ZBP1 in adult dermatomyositis (DM) (n=41) and H. Correlation with IFN score by linear regression. I. ZBP1 expression in juvenile dermatomyositis (jDM, n=9) compared to CTL (n=8). J. Representative images of tissue imunofluoresence of ZBP1 in CTL (n= 7), DLE (n=8), SCLE (n=5) and DM (n=6). Dotted white line indicates the dermo-epidermal junction. Scale bar =100μm. Mean + SEM. * = q < 0.05; ** = q < 0.01; *** = q < 0.0001, by Studenťs unpaired t-test.