Extended Data Fig. 7. Immune correlates of protection.
a, Correlation of pre-challenge, BQ.1.1-specific mucosal and peripheral NAb, ELISA IgG, ELISA IgA, and CD8+ and CD4+ T cell responses with peak log sgRNA levels in BAL and NS following SARS-CoV-2 BQ.1.1 challenge. Two-sided Spearman rank-correlation tests were performed, and R and P values are shown. b, Multivariable analysis of stepwise regression of peak sgRNA with immunologic parameters with multiple comparison adjustments.