Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Dec 14;626(7998):385–391. doi: 10.1038/s41586-023-06951-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 10 — The heatmap (left) illustrates the normalized enrichment scores (NES) of pathways for different groups at weeks 1 and 6 following immunization relative to the no boost group. The colour scale represents the NES, ranging from downregulated pathways (blue) to no change (white) to upregulated pathways (orange). The colour intensity reflects the strength of the enrichment score, with darker colours indicating stronger upregulation or downregulation. Pathways were selected using a GSEA nominal P-value of 0.05. P-values were corrected for multiple testing using the false discovery rate FDR cutoff of 0.05. n = 40 biologically independent animals were included in this analysis. The summary cartoon (right) shows that IT boosting led to robust and sustained activation of cytokine, NK, T and B cell pathways in the lung for at least 6 weeks. The diagram was created using BioRender.