Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Feb 7;15:902. doi: 10.1038/s41467-024-45046-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a Overall structure of the S3E-LysoPS-bound receptor. Disulfide bonds are shown as sticks. b Interactions between extracellular loop (ECL)2 and transmembrane helices (TMs). Black dashed lines indicate hydrogen-bonding interactions. c, d Cross-sectional views of the ligand-binding pocket, viewed from the membrane plane (c) and the extracellular side (d). e, f Binding mode of S3E-LysoPS in the hydrophilic (e) and hydrophobic (f) pockets of the receptor. g Mutagenesis data for identifying the S3E-LysoPS interaction residues (n = 8 for the wild type and n = 5 for the mutants). Values are shown as the mean ± s.e.m. from at least three independent experiments performed in triplicate. Source data are provided as a Source Data file.