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. 2024 Feb 7;15:1148. doi: 10.1038/s41467-024-45324-w

Fig. 7. The AR-FUT4 axis promotes accumulation of lung intravascular melanoma colonies in vivo.

Fig. 7

a Experimental design for mouse tumor model. b (upper) The growth curve and end-point fold-change of EV/FUT4-OE WM793 tumors subcutaneously implanted in NSG mice fed with control (CTL) or enzalutamide (Enzal) diet (EV-CTL diet, n = 10 mice; EV-Enzal diet, n = 9 mice; FUT4-OE-CTL diet, n = 8 mice; FUT4-OE-Enzal diet, n = 10 mice). (lower) Representative images of primary tumors at the end point. c (left) Quantification of lung intravascular melanoma colonies (n = 4 lungs per group) and (right) representative H&E staining and corresponding IF staining of lung intravascular melanoma colonies in mice harboring FUT4-OE melanoma tumors fed with CTL diet. Scale bar = 100 μm. For b, c, data are presented as mean values ± SEM and p-values are calculated by two-sided Student’s t-test. Source data are provided as a Source Data file.