Table 2.
Comparison of lipid/apoAI molar ratios at baseline (D0) in the total HDL fraction (d 1.063–1.21 g/ml) in HTG subjects with healthy controls and the effect of pitavastatin treatment (D180) on baseline values in the HTG group
|
Lipid Class |
Baseline (D0) versus Control |
Poststatin (D180) versus Baseline (D0) |
||
|---|---|---|---|---|
| Mean % Differencea | P-valueb | Mean % Differencec | P-valueb | |
| Dihydroceramide | −36.6 | 2.54E-05 | 26.6 | 3.12E-02 |
| Ceramide | −49.7 | 5.35E-06 | 40.3 | 7.71E-03 |
| Monohexocylceramide | −52.7 | 8.25E-06 | 37.5 | 1.32E-02 |
| Dihexosylceramide | −52.3 | 1.43E-05 | 33.2 | 2.03E-02 |
| Trihexosylceramide | −55.5 | 5.35E-06 | 29.3 | 6.76E-03 |
| GM3 ganglioside | −55.1 | 1.37E-08 | 39.4 | 6.76E-03 |
| Sphingomyelin | −47.5 | 3.76E-06 | 49.2 | 6.76E-03 |
| Phosphatidylcholine | −37.3 | 3.94E-06 | 30.9 | 1.95E-02 |
| Alkylphosphatidylcholine | −45.8 | 2.57E-04 | 43.0 | 6.76E-03 |
| Phosphatidylcholine plasmalogen | −54.7 | 1.43E-05 | 40.1 | 6.76E-03 |
| Lysophosphatidylcholine | −50.0 | 3.97E-03 | 12.9 | 6.49E-01 |
| Lysoalkylphosphatidylcholine | −49.0 | 1.11E-04 | 13.9 | 4.62E-01 |
| Phosphatidylethanolamine | −28.9 | 1.51E-01 | 24.1 | 1.30E-01 |
| Alkylphosphatidylethanolamine | −58.2 | 1.88E-04 | 62.9 | 6.69E-02 |
| Phosphatidylethanolamine plasmalogen | −59.4 | 4.63E-05 | 51.2 | 7.71E-03 |
| Lysophosphatidylethanolamine | −42.7 | 1.37E-03 | 11.6 | 5.47E-01 |
| Phosphatidylinositol | −40.2 | 2.11E-05 | 20.0 | 2.75E-01 |
| Lysophosphatidylinositol | −73.7 | 2.15E-03 | 109.2 | 7.59E-02 |
| Phosphatidylserine | −52.0 | 6.50E-04 | 12.4 | 7.63E-01 |
| Free cholesterol | −48.4 | 2.58E-06 | 28.6 | 1.32E-02 |
| Cholesteryl ester | −27.1 | 1.76E-04 | 18.9 | 3.31E-02 |
| Diacylglycerol | 27.4 | 1.10E-01 | −4.3 | 7.63E-01 |
| Triacylglycerol | 15.6 | 3.83E-01 | −4.6 | 7.63E-01 |
CE, cholesteryl ester; Cer, ceramide; COH, free cholesterol; DAG, diacylglycerol; dhCer, dihydroceramide; DHC, dihexosylceramide; GM, GM3 ganglioside; LPI, lysophosphatidylinositol; MHC, monohexocylceramide; PC, phosphatidylcholine; PC(O), alkylphosphatidylcholine; PE(P), phosphatidylethanolamine plasmalogen; PI, phosphatidylinositol; PS, phosphatidylserine; SM, sphingomyelin; TAG, triacylglycerol; THC, trihexosylceramide.
Mean percentage difference between baseline (D0) values in the HTG group (n = 12) taking Healthy Controls (n = 10) as reference.
Significance determined by t test; P-values were corrected for multiple comparisons by the method of Benjamini–Hochberg; bold indicates corrected P-values <0.05.
Mean percentage difference, taking Baseline (D0) in the HTG group as reference.