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. 2024 Jan 25;11:1322773. doi: 10.3389/fchem.2023.1322773

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Copyright © 2024 Metebi, Kauffman, Xu, Singh, Nayback, Fan, Johnson, Diemer, Grimm, Zamiara and Zinn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fractionated intraperitoneal treatments of Pb-214/Bi-214-TCMC-Trastuzumab suppress peritoneal human OVCAR3 ovarian tumor growth in a nude mouse model (A–C). (A) Design for study #3, (B) representative images before and after treatment with Pb-214/Bi214-TCMC-Trastuzumab, and (C) summary of bioluminescence imaging results for mice with OVCAR3 tumors treated with Pb-214/Bi-214-TCMC-Trastuzumab, Pb-214/Bi-214-TCMC-IgG, and untreated in Balb/c nude mice. **, p < 0.01 compared to untreated control; n.s., not significant.