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. 2024 Jan 25;11:1340199. doi: 10.3389/fcvm.2024.1340199

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© 2024 Yu, Zhang, Yang, Aikebaier, Shan, Zha and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The associations between diagnostic genes, pyroptosis-related genes and CAVD-related genes. (A) Pearson's correlation analysis. Diagnostic genes and pyroptosis-related genes were positively correlated with IL6 and TNF, which promote the CAVD progression, but negatively correlated with SOX9 which suppresses the disease development. (B) The PPI networks. Complicated interactions between diagnostic genes (TREM1, TNFRSF11B and PGF), pyroptosis-related genes (CASP1, NLRP3, PYCARD, IL1B and IL18) and CAVD-related genes (IL6, TNF and SOX9).