Table 2.
Effects of magnolol on the lifespan of N2 C. elegans.
| Strain | Group | Number | Mean life (days) |
Maximum longevity (days) |
Median survival time (days) |
Increase (%) | p value |
|---|---|---|---|---|---|---|---|
| N2 | Vehicle | 142 | 19.480 ± 0.383 | 28 | 20.00 | / | / |
| Magnolol-2.5 μM | 175 | 21.120 ± 0.330 | 31 | 20.00 | 8.42 | 0.01** | |
| Magnolol-5 μM | 128 | 22.039 ± 0.400 | 31 | 23.00 | 13.14 | < 0.001*** | |
| Magnolol-10 μM | 146 | 21.384 ± 0.376 | 31 | 20.00 | 9.78 | < 0.001*** | |
| Magnolol-25 μM | 184 | 20.533 ± 0.351 | 31 | 20.00 | 5.4 | 0.008** |
Lifespan experiments were analysed using Kaplan–Meier survival analysis and compared among groups, scoring for significance using the log-rank test. All data were expressed as mean ± SEM. **p < 0.01, ***p < 0.001 versus control group.