TABLE 3.
Large animal models of OA and associated injection vehicle.
| Author (Year) | Animal (n) | OA model | Joint injected | Cell type | Vehicle |
|---|---|---|---|---|---|
| Al Faqeh et al. (2012) | Sheep (16) | ACLT + MX | Knee | BM-MSCs | Culture media |
| Guercio et al. (2012) | Dog (4) | Spontaneous OA | Knee | AT-MSCs | PRP or HA |
| Jiang et al. (2014) | Rhesus macaques (27) | Collagenase | Knee | BM-MSCs | Normal saline |
| Song et al. (2014) | Sheep (18) | ACLT + MX | Knee | BM-MSCs | PBS |
| Tsai et al. (2014) | Dog (3) | Spontaneous OA | Knee | AT-MSCs | PBS |
| Ude et al. (2014) | Sheep (18) | ACLT + MX | Knee | Chondrogenically-induced AT-MSCs and BM-MSCs | Culture media |
| Delling et al. (2015) | Sheep (12) | MX | Knee | BM-MSCs | PBS |
| Desando et al. (2016) | Sheep (20) | MX | Knee | BM-MSCs | HA |
| Yun et al. (2016) | Dog (24) | ACLT | Knee | AT-MSCs | PBS or PRP |
| Barrachina et al. (2018) | Horse (18) | Amphotericin-B | Knee | BM-MSCs | RL |
| Feng et al. (2018) | Sheep (30) | ACLT + MX | Knee | AT-MSCs | HA |
| Lv et al. (2018) | Sheep (34) | ACLT + MX | Knee | AT-MSCs | HA |
| Srzentić Dražilov et al. (2018) | Dog (10) | Spontaneous OA | Various | AT-MSCs | PBS |
| Ude et al. (2018) | Sheep (18) | ACLT + MX | Knee | Chondrogenically-induced AT-MSCs and BM-MSCs | Culture media |
| Cabon et al. (2019) | Dog (22) | Spontaneous OA | Various | MSCs from neonatal tissues | PBS |
| Jiang et al. (2019) | Rhesus macaques (8) | Spontaneous OA | Knee | Embryonic or BM-MSCs | Normal saline |
| Oh et al. (2021) | Dog (16) | ACLT | Knee | AT-MSCs | Normal saline |
| Sanghani-Kerai et al. (2021) | Dog (25) | Spontaneous OA | Various | AT-MSCs | PRP |
| Armitage et al. (2022) | Dog (245) | Spontaneous OA | Various | AT-MSCs | PRP |
ACLT, anterior cruciate ligament transection; AT, adipose tissue-derived; BM, bone marrow derived; HA, hyaluronic acid; MSCs, mesenchymal stromal cells; MX, meniscectomy; PBS, phosphate buffered saline; PRP, platelet rich plasma; RL, ringer’s lactate.