Table 3.
Total prevalence of NTDs per 10 000 total births (±95% CIs) by region, as registered by regional registers (2000–2014) and NCARDRS for the periods of reporting (2015–2019)
| Regional register | Time period | NTD prevalence | Anencephaly prevalence | Spina bifida prevalence |
| EMSY (legacy) | 2000–2013 | 11.86 (11.16 to 12.60) | 4.93 (4.48 to 5.42) | 5.72 (5.23 to 6.24) |
| EMSY (NCARDRS) | 2016–2019 | 12.78 (11.49 to 14.17) | 6.52 (5.61 to 7.53) | 5.27 (4.46 to 6.19) |
| Northern (legacy) | 2000–2014 | 14.83 (13.76 to 15.96) | 6.01 (5.34 to 6.74) | 7.36 (6.61 to 8.17) |
| Northern (NCARDRS) | 2015–2019 | 14.22 (12.39 to 16.24) | 6.75 (5.51 to 8.18) | 6.03 (4.86 to 7.39) |
| South West (legacy) | 2003–2014 | 11.57 (10.72 to 12.48) | 4.50 (3.98 to 5.08) | 5.74 (5.15 to 6.39) |
| South West (NCARDRS) | 2015–2019 | 13.83 (12.37 to 15.40) | 6.05 (5.10 to 7.12) | 6.35 (5.37 to 7.44) |
| Thames Valley (legacy) | 2005–2014 | 10.77 (9.63 to 12.01) | 4.60 (3.87 to 5.44) | 4.90 (4.14 to 5.76) |
| Thames Valley (NCARDRS) | 2015–2019 | 13.16 (11.34 to 15.18) | 5.63 (4.46 to 7.01) | 5.70 (4.53 to 7.08) |
| Wessex (legacy) | 2000–2014 | 11.09 (10.12 to 12.14) | 5.99 (5.28 to 6.77) | 3.96 (3.39 to 4.60) |
| Wessex (NCARDRS) | 2015–2019 | 14.55 (12.65 to 16.66) | 6.03 (4.83 to 7.43) | 6.79 (5.51 to 8.27) |
*Legacy refers to those regional registers in existence prior to the transition to NCARDRS. We have used a cut-off of 2015—some cases in 2015 were collected by the legacy registers and some cases in 2014 were collected by NCARDRS.
EMSY, East Midlands and South Yorkshire; NCARDRS, National Congenital Anomaly and Rare Disease Registration Service; NTD, neural tube defect.