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Type I/II cytokine receptors. Type I/II family cytokines signal through different heteromeric receptors which define the family (box 1). Members of the type I/II cytokine family include interleukins (ILs), interferons (IFNs), IFN-like cytokines, colony-stimulating factors, hormones and growth factors. The combinatorial complexity of cytokine receptor signalling is mediated by specific binding of JAK isoforms to intracellular domains and subsequent activation of STATs.
