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. 2023 Nov 3;83(2):139–160. doi: 10.1136/ard-2023-223850

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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JAK-STAT signalling pathway. (A) Individual JAKs are constitutively associated with their specific receptors through their FERM and SH2 domains. (B) On cytokine engagement, JAKs become activated and phosphorylate each other, as well as the intracellular tails of their receptors. (C) Phosphorylation of the receptor chains generates docking sites for STATs, which can bind to the cytoplasmic domain of the receptor facilitating JAK-mediated STAT phosphorylation. (D) Phosphorylated STATs dimerise, translocate to the nucleus and bind to DNA, thereby regulating gene transcription.