Figure 5.

Traveling Waves (TW) improved the mitochondrial function of hiPSC-derived closed-loop cardiac tissue (iCT)

(A) Results of oxygen consumption rate (OCR) assays. Oligo, oligomycin; FCCP, carbonyl cyanide-4-(trifluoromethoxy) phenylhydrazone; ROTE/ANTI, rotenone and antimycin A.

(B–F) Quantification of the basal respiration (b), ATP production (c), proton leak (d), maximal respiration capacity (e), and spare capacity (f) (Control: n = 7; TW: n = 6 biologically independent samples from one differentiation). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 (Student’s t test).