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Survival curves as a function of time following i.p. bacterial challenge (5 × 108 CFU) in wild-type (C57BL/6) mice pretreated with anti-mouse IgG (Sham) (A) or anti-IL-1R1 MAb (B). n, number/group; ∗, P < 0.000001 and α < 0.0001, by χ2 analysis and post hoc Fisher exact tests, respectively. Note that the abscissas are not on a linear scale.
