TABLE 1.
Bacterial infection decreased SP-A concentrations in lung homogenates
| Mice | SP-A concn (ng/ml) in lung homogenate from mice injected with P. aeruginosaa:
|
||
|---|---|---|---|
| PBS |
P. aeruginosa
|
||
| 6 h postinfection | 24 h postinfection | ||
| Wild type | 357 ± 19 | 267 ± 85 | 197 ± 9† |
| CCSP-IL-4 | 953 ± 73* | 682 ± 72* | 357 ± 11*† |
| Treated i.n. with IL-4 | 378 ± 148 | 263 ± 79 | ND |
a
Mean ± SEM for three mice per group. ND, not done; *, P < 0.05 compared to wild-type mice, as assessed by ANOVA; †, P < 0.05 compared to PBS-injected control mice, as assessed by ANOVA.