Skip to main content
. 2023 Nov 29;9(2):334–346. doi: 10.1016/j.ekir.2023.11.020

Table 3.

Summarized potential functions of the differentially excreted proteins. The 19 unique proteins of which the SGLT2i-affected urinary peptide fragments were derived from together with the directionality of dapagliflozin-induced change and their molecular weights (in Daltons).29 The potential roles of the proteins were obtained from the referenced studies and the Human Protein Atlas30

UniProt ID Gene Symbol Protein Change Molecular weight (Da) Potential Role in DKD
P04217 A1BG α-1B-glycoprotein - 54,254 Proteinuria biomarker31
P02768 ALB Serum albumin - 69,367 Proteinuria biomarker31
P02765 AHSG α-2-HS-glycoprotein + 39,341 Tissue development, endocytosis, inflammation,32 proteinuria biomarker31
P02656 APOC3 Apolipoprotein C-III + 10,852 Lipoprotein metabolism & inhibitor of lipolysis33
Q05682 CALD1 Caldesmon - 93,231 Actin cytoskeleton organization,34,35 regulation of mesangial cell activation36
P02452 COL1A1 Collagen α-1(I) chain + 138,941 Extracellular matrix organization31,32
P02461 COL3A1 Collagen α-1(III) chain + 138,564 Extracellular matrix organization31
P08123 COL1A2 Collagen α-2(I) chain + 129,314 Extracellular matrix organization31,32
Q9UBG3 CRNN Cornulin - 53,533 Repair,31 positive regulation of NF-κB transcription factor activity37
Q8IY81 FTSJ3 pre-rRNA processing protein FTSJ3 + 96,558 Unknown
P08238 HSP90AB1 Heat shock protein HSP 90-β - 83,264 Regulation of TGF-β signaling,38 immunity & inflammation,39 stress response in wound healing40
B9A064 IGLL5 Immunoglobulin λ-like polypeptide 5 - 23,063 Inflammation41
P04264 KRT1 Keratin; type II cytoskeletal 1 + 66,039 Inflammation31, coagulation,30 extracellular matrix,30 and wound healing30
Q6UXB8 PI16 Peptidase inhibitor 16 - 49,471 Extracellular matrix organisation31
P01833 PIGR Polymeric immunoglobulin receptor + 83,284 Tubular response to injury42
P41222 PTGDS Prostaglandin-H2 D-isomerase - 21,029 Inhibition of TGF-β induced EMT,43,44 GFR biomarker31
Q8WVN6 SECTM1 Secreted and transmembrane protein 1 - 27,039 Inflammation,45 NF-κB pathway activation30
P01009 SERPINA1 α-1-antitrypsin - 46,737 Inflammation, coagulation and proteinuria biomarker,31,32 kidney fibrosis46
Q9UPN9 TRIM33 E3 ubiquitin-protein ligase TRIM33 + 122,533 Regulation of TGF-β pathway,47,48 inflammation & fibrosis47

DKD, diabetic kidney disease; EMT, epithelial–mesenchymal transformation; GFR, glomerular filtration rate.