Table 2.
Follow-up data in total and by baseline eGFR
| Total |
Baseline eGFR (ml/min per 1.73 m2) |
aP value | bP value for trend | |||
|---|---|---|---|---|---|---|
| >60 |
30–60 |
<30 |
||||
| (n = 155) | (n = 17) | (n = 65) | (n = 73) | |||
| No. of simultaneous measurements of eGFR and ACR | 21 (11, 46) | 41 (25, 64) | 25 (14, 51) | 15 (10, 27) | 0.024 | <0.001 |
| Time to ESKD (yr) | 3.3 (1.6, 6.0) | 8.8 (5.6, 11.5) | 4.2 (2.5, 8.2) | 2.2 (1.0, 3.9) | <0.001 | <0.001 |
| eGFR | ||||||
| cPattern of eGFR | 0.269 | 0.107 | ||||
| Linear | 13 (8.4%) | 1 (5.9%) | 3 (4.6%) | 9 (12.3%) | ||
| Curvilinear | 142 (91.6%) | 16 (94.1%) | 62 (95.4%) | 64 (87.7%) | ||
| Coefficient of variation for eGFR | 43.1 (34.4, 56.1) | 58.7 (56.1, 66.9) | 46.3 (38.4, 58.8) | 36.8 (29.0, 44.2) | <0.001 | <0.001 |
| ACR | ||||||
| dPattern of albuminuria | 0.373 | 0.142 | ||||
| Progression | 51 (32.9%) | 9 (52.9%) | 21 (32.3%) | 21 (28.8%) | ||
| Regression | 17 (11.0%) | 2 (11.8%) | 6 (9.2%) | 9 (12.3%) | ||
| No change | 87 (56.1%) | 6 (35.3%) | 38 (58.5%) | 43 (58.9%) | ||
| Coefficient of variation for albuminuria | 48.9 (36.9, 68.2) | 57.8 (48.7, 70.6) | 50.8 (37.4, 69.8) | 42.2 (30.2, 59.1) | 0.077 | 0.003 |
| Compound annual growth rate for albuminuria (%) | 43.6 (0.0, 102.5) | 50.4 (32.9, 93.8) | 39.1 (3.9, 100.1) | 49.9 (-8.0, 118.9) | 0.925 | 0.633 |
| No. of patients who developed nephrotic-range albuminuria | 131 (84.5%) | 15 (88.2) | 55 (84.6) | 61 (83.6) | 0.891 | 0.661 |
ACR, urine albumin-to-creatinine ratio; eGFR, estimated glomerular filtration rate; ESKD, end-stage kidney disease.
Data are presented as median (interquartile range) for continuous measures, and n (%) for categorical measures.
P value calculated by analysis of variance for continuous variables and χ2 tests for categorical variables and represents differences across categories of eGFR.
P value calculated by a nonparametric test for trend across ordered groups.
The pattern of eGFR in each patient was determined based on the analysis of variance F-test by applying a generalized additive mixed model and a linear model to each patient’s eGFR data (See Statistical Analyses in the Methods section and Supplementary Table S1).
The pattern of albuminuria was quantified as follows: progression of albuminuria was defined as a permanent transition from a lower albuminuria category to a higher albuminuria category, and a decrease in albuminuria was defined as the opposite. Remaining in the same category as the baseline status was defined as no change (See Statistical Analyses in the Methods section).