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. 2023 Nov 19;9(2):370–382. doi: 10.1016/j.ekir.2023.11.008

Figure 4.

Figure 4

Histopathologic spectrum of tubulointerstitial findings in ABBA. (a) Mild acute tubular injury, characterized by apical cytoplasmic blebbing and attenuation of brush borders of the proximal tubules (PAS stain, original magnification 200x, scale bar = 50 μm). (b) Acute on chronic tubular injury with interstitial fibrosis and edema separating tubular profiles, epithelial simplification, and dilation (hematoxylin and eosin stain, original magnification 200 x, scale bar = 50 μm). (c) Granulomatous interstitial nephritis, characterized by lymphocytic interstitial inflammation, epitheliod histiocytes, and a giant cell reaction (PAS stain, original magnification 400x, scale bar = 20 μm). (d) Dense monomorphic lymphoid infiltrate within interstitium (hematoxylin and eosin stain, original magnification 400x, scale bar = 20 μm). (e) CD3 immunohistochemistry of the case shown in (d) demonstrating CD3+ T cells make up the minority of the interstitial lymphoid infiltrate (CD3 immunoperoxidase staining, original magnification 40x, scale bar = 200 μm). (f) CD20 immunohistochemistry of the case shown in (d) and (e) showing a predominance of CD20+ B cells within the lymphoid infiltrate, consistent with involvement by a low-grade B cell lymphoma in a patient with known lymphoplasmacytic lymphoma (CD20 immunoperoxidase staining, original magnification 40x, scale bar = 200 μm). ABBA, antibrush border antibody disease; PAS, periodic acid-Schiff; TBM, tubular basement membrane.