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Effects of pioglitazone (A) and RDs # 33a (B), 33b (C), 33c (D), 33d (E), 33e (F), 33f (G), and 33g (H) on insulin secretion by βTC6 cells in the absence (basal) and presence of 2.8 mM glucose. Drug concentrations of 10–12–10–6 M were used. The results are means of triplicates ± SEM; *P < 0.05, **P < 0.01, and ***P < 0.001 from relative basal control, and #P < 0.05, ##P < 0.01, and ###P < 0.001 from glucose 2.8 mM.
