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. 2024 Jan 8;63(3):264–272. doi: 10.1021/acs.biochem.3c00536

Table 1. Dissociation Constants (Kd, μM) and Relative Fold Change in Binding Affinity (FC) of PAN Endonuclease Variants with BXA and 23.

  BXA
 23
  Kd (μM) relative affinity Kd (μM) relative affinity
WT 0.343 ± 0.106   277 ± 30.6  
I38T 9.3 ± 4.2 27-fold 384 ± 19.4 1.4-fold
E23K 26.1 ± 11.2 79-fold 328 ± 26.6 1.2-fold