Table 1. Top 20 Interdomain DI Pairs.

interdom. rank (75,259 total)	global rank (152,076 total)	ranked DI pairs	matched to 5JO7 (HPS)	matched to 5EAT (TEAS)	HPS dist. (Å)b	TEAS dist. (Å)	HPS residues	TEAS residues
1	3	212–240	212–239	204–232	4.9	4.9	R–D	R–D
2	12	173–497	173–496	165–489	2.9	6.9	E–K	E–K
3	13	47–235	47–234	45–227	2.6	2.9	E–R	E–R
4	15	82–236	82–235	79–228	3.7	3.6	I–F	I–F
5	18	84–289	84–288	81–281	3.5	4.1	Y–P	Y–P
6 (1)a	20	224–238	223–237	216–230	2.4	2.8	E–K	D–K
7	27	167–498	167–497	159–490	2.6	3.0	H–D	H–D
8	46	213–526	213–525	205–518	6.3	5.2	V–V	V–V
9	74	82–240	82–239	79–232	3.9	4.0	I–D	I–D
10 (2)	77	204–525	204–524	196–517	2.9	5.2	Q–D	Q–E
11 (3)	83	209–526	209–525	201–518	3.8	4.0	S–V	G–V
12	88	85–240	85–239	82–232	2.5	2.9	H–D	H–D
13 (4)	100	84–287	84–286	81–279	6.5	3.8	Y–A	Y–F
14	125	48–236	48–235	46–228	3.8	3.9	I–F	I–F
15 (5)	143	208–493	208–492	200–485	6.4	5.9	K–D	K–E
16 (6)	148	165–493	165–492	157–485	5.8	6.2	R–D	R–E
17	152	167–501	167–500	159–493	4.0	3.3	H–E	H–E
18 (7)	153	204–529	204–528	196–521	2.8	3.9	Q–K	Q–I
19	179	166–504	166–503	158–496	5.1	4.3	T–L	T–L
20	181	53–443	53–442	51–435	37.9	37.3	E–A	E–A

^aDI pairs in bold with rankings in parentheses are those in which one of the amino acid residues differs between TEAS and HPS.

^bReported distances are from chain A and are between the closest heteroatoms of the two amino acids noted.