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. 2024 Feb 7;22:54. doi: 10.1186/s12951-024-02320-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Transcriptome analysis of BMSCs gene expression in different groups. (a) PCA analysis of all data of GO, 0.1KBGO, and 0.1KBGO + US groups. (b) Pearson correlation coefficient heatmap of all samples. (c) Venn diagram of the number of differentially expressed genes among GO, 0.1KBGO, and 0.1KBGO + US groups. (d-f) Volcano analysis of differentially expressed genes of 0.1KBGO + US vs. GO, 0.1KBGO + US vs. 0.1KBGO, and 0.1KBGO vs. GO. (g-h) The top 20 significant up-enriched GO terms of 0.1KBGO + US vs. GO and 0.1KBGO + US vs. 0.1KBGO. (i-j) The top 20 significant up-enriched KEGG pathways of 0.1KBGO + US vs. GO and 0.1KBGO + US vs. 0.1KBGO. (k) Heatmap of the represented up-regulated genes in GO, 0.1KBGO, and 0.1KBGO + US. n = 3 biological replicates per group