Table 4.
Univariate logistic regression analysis of risk factors for postoperative 90-day complications
| Variables | Number (%) | OR | 95% CI | P value |
|---|---|---|---|---|
| Age (> 65) | 45 (57.7) | 2.8 | 0.899–8.717 | 0.076 |
| Gender (male) | 64 (84.2) | 1.326 | 0.330–5.335 | 0.691 |
| Smoking history | ||||
| Non-smoker | 34 (43.6) | 1.000 | - | |
| Ex-smoker | 20 (25.6) | 1.538 | 0.405–5.842 | 0.527 |
| Current smoker | 24 (30.8) | 3.333 | 0.824–13.482 | 0.091 |
| Smoking index (package-years) | 1.006 | 0.992–1.020 | 0.406 | |
| Comorbidity | 58 (74.4) | 9.256 | 1.151–74.412 | 0.036 |
| Age-adjusted Charlson Comorbidity Index | ||||
| Score ≤ 3 | 44 (56.4) | 1.000 | - | 0.002 |
| Score > 4 | 34 (43.6) | 6.158 | 1.948–19.470 | |
| PFT | ||||
| FEV1 (% pred) < 70% | 34 (43.6) | 0.821 | 0.292–2.306 | 0.708 |
| FVC (% pred) < 70% | 24 (30.8) | 0.684 | 0.216–2.163 | 0.518 |
| FEV1/FVC (% pred) < 70% | 21 (26.9) | 0.875 | 0.273–2.804 | 0.822 |
| MVV (% pred) < 70% | 36 (46.2) | 0.714 | 0.254–2.005 | 0.523 |
| DLCO (% pred) < 60% | 31 (39.7) | 1.339 | 0.479–3.744 | 0.578 |
| Preoperative prophylaxis for ILD | 17 (21.8) | 1.278 | 0.387–4.221 | 1.278 |
| History of AE-ILD | 14 (17.9) | 1.815 | 0.527–6.251 | 0.345 |
| Surgical approach | ||||
| VATS | 68 (87.2) | 1.000 | - | |
| Thoracotomy | 10 (12.8) | 1.286 | 0.299–5.534 | 0.736 |
| Extent of resection | ||||
| Sublobectomy | 49 (62.8) | 1.000 | - | - |
| Lobectomy or more | 29 (37.2) | 3.618 | 1.256–10.424 | 0.017 |
| Systematic lymph node dissection | 50 (64.1) | 4.293 | 1.132–16.278 | 0.032 |
| Operation time (min) | 1.010 | 1.002–1.018 | 0.011 | |
| Intraoperative blood loss (ml) | 1.005 | 1.001–1.008 | 0.008 | |
| Intraoperative accident or blood transfusion | 12 (15.4) | 0.412 | 0.114–1.487 | 0.176 |
| Pathology of pulmonary lesion | ||||
| Benign | 28 (35.9) | 1.000 | - | |
| Malignant | 50 (64.1) | 4.293 | 1.132–16.278 | 0.032 |
Abbreviation: AE-ILD: acute exacerbation of ILD; CI: confidential interval; DLCO: diffusing capacity of carbon monoxide; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; min: minute; MVV: maximal voluntary ventilation; ml: milliliter; OR: Odds ratio; PFT: pulmonary function test;