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. Author manuscript; available in PMC: 2024 Feb 8.
Published in final edited form as: Drug Alcohol Depend. 2023 Jun 9;249:110822. doi: 10.1016/j.drugalcdep.2023.110822

Table 2.

Illegal SUD Factors and Residual Variances of Specific SUDs at Waves 1, 2, and 3 Regressed on Positive and Negative SEs for Each Substance and CD Symptoms, Controlling for Sex

Hallucinogens
Illegal SUD Factor Residual Variance of Hallucinogen SUD Illegal SUD Factor Residual Variance of Hallucinogen SUD
β p-value β p-value β p-value β p-value

Wave 1 (N =275)
 Hallucinogen Positive SEs .197** [.052, .342] .008 .135* [.010, .261] .035 Hallucinogen Negative SEs .382*** [.257, .507] < .001 .086 [−.050, .222] .214
 CD Symptoms .292*** [.144, .440] < .001 −.023 [−.159, .113] .742 CD Symptoms .275*** [.133, .416] < .001 −.018 [−.151, .116] .795
Wave 2 (N = 178)
 Hallucinogen Positive SEs .020 [−.205, .245] .860 .075 [−.101, .251] .402 Hallucinogen Negative SEs .221* [.003, .439] .047 .064 [−.129, .257] .517
 CD Symptoms .071 [−.163, .304] .552 .002 [−.178, .182] .980 CD Symptoms .075 [−.171, .320] .552 .005 [−.172, .183] .954
Wave 3 (N = 160)
 Hallucinogen Positive SEs −.133 [−.381, .115] .292 .169 [−.045, .384] .122 Hallucinogen Negative SEs .273* [.056, .489] .014 .100 [−.094, .294] .313
 CD Symptoms −.068 [−.324, .188] .603 −.110 [−.318, .097] .297 CD Symptoms −.142 [−.395, .111] .271 −.086 [−.299, .127] .428

Amphetamines
Illegal SUD Factor Residual Variance of Amphetamine SUD Illegal SUD Factor Residual Variance of Amphetamine SUD
β p-value β p-value β p-value β p-value

Wave 1 (N = 220)
 Amphetamine Positive SEs −.001 [−.179, .176] .988 .378*** [.249, .507] < .001 Amphetamine Negative SEs .220** [.062, .378] .006 .169* [.040, .299] .011
 CD Symptoms .249** [.073, .425] .006 .019 [−.127, .164] .802 CD Symptoms .241** [.066, .415] 007 .043 [−.111, .197] .586
Wave 2 (N = 130)
 Amphetamine Positive SEs −.008 [−.251, .236] .950 .031 [−.168, .230] .762 Amphetamine Negative SEs .084 [−.138, .307] .458 −.064 [−.262, .135] .530
 CD Symptoms −.001 [−.254, .252] .994 −.183 [−.408, .042] .110 CD Symptoms −.007 [−.250, .235] .952 −.184 [−.408, .040] .107
Wave 3 (N = 113)
 Amphetamine Positive SEs .113 [−.308, .533] .599 −.132 [−.435, .172] .394 Amphetamine Negative SEs .161 [−.284, .606] .478 −.188 [−.544, .167] .299
 CD Symptoms −.044 [−.447, .358] .829 −.181 [−.465, .103] .212 CD Symptoms −.036 [−.466, .393] .868 −.180 [−.491, .131] .258

Cocaine
Illegal SUD Factor Residual Variance of Cocaine SUD Illegal SUD Factor Residual Variance of Cocaine SUD
β p-value β p-value β p-value β p-value

Wave 1 (N = 231)
 Cocaine Positive SEs .241** [.082, .401] .003 .102 [−.044, .247] .170 Cocaine Negative SEs .184* [.023, .344] .025 .111 [−.021, .243] .098
 CD Symptoms .278*** [.119, .437] .001 −.019 [−.164, .126] .797 CD Symptoms .268*** [.109, .427] .001 −.032 [−.178, .114] .665
Wave 2 (N = 133)
 Cocaine Positive SEs N/A N/A .048 [−.168, .264] .666 Cocaine Negative SEs N/A N/A .089 [−.115, .293] .395
 CD Symptoms N/A+ N/A −.081 [−.302, .139] .471 CD Symptoms N/A N/A −.092 [−.313, .129] .415
Wave 3 (N = 127)
 Cocaine Positive SEs −.055 [−.333, .223] .697 −.030 [−.224, .165] .765 Cocaine Negative SEs .097 [−.159, .353] .458 −.109 [−.326, .108] .325
 CD Symptoms −.213 [−.490, .064] .131 .122 [−.097, .341] .275 CD Symptoms −.217 [−.491, .057] .121 .128 [−.091, .348] .252

Opioids
Illegal SUD Factor Residual Variance of Opioid SUD Illegal SUD Factor Residual Variance of Opioid SUD
β p-value β p-value β p-value β p-value

Wave 1 (N = 178)
 Opioid Positive SEs .021 [−.184, .227] .838 .248** [.080, .416] .004 Opioid Negative SEs .258** [.076, .441] .006 .268** [.103, .434] .002
 CD Symptoms .268** [.098, .439] .002 −.102 [−.287, .083] .280 CD Symptoms .296*** [.129, .464] .001 −.073 [−.255, .109] .433
Wave 2 (N = 110)
 Opioid Positive SEs .054 [−.180, .287] .652 .224 [−.092, .540] .164 Opioid Negative SEs −.159 [−.475, .156] .322 .425** [.115, .736] .007
 CD Symptoms −.124 [−.410, .162] .395 .044 [−.312, .400] .809 CD Symptoms −.229 [−.584, .126] .206 .217 [−.248, .682] .361
Wave 3 (N = 106)
 Opioid Positive SEs −.027 [−.325, .271] .179 .295* [.036, .554]. .026 Opioid Negative SEs .095 [−.215, .406] .547 .148 [−.104, .400] .249
 CD Symptoms −.318 [−.688, .051] .091 .026 [−.422, .474] .910 CD Symptoms −.312 [−.699, .075] .114 .035 [−.440, .510] .885
*

p < .05

**

p < .01

***

p ≤ .001

Bolded estimate: FDR p < .05

+

At Wave 2, we were unable to regress cocaine positive SEs on the general SUD factor, due to small cell sizes

Note: Reported Ns include individuals with data for both SEs and SUDs for that specific substance.