Table 2.

Associations of Alpha-Diversity With Glaucoma, Intraocular Pressure, and Vertical Cup-to-Disc Ratio

	Glaucoma		Intraocular Pressure		Vertical Cup-to-Disc Ratio
	OR (95% CI)	P Value	Beta (95% CI)	P Value	Beta (95% CI)	P Value
Simpson's diversity index	2.38 (0.26 to 21.77)	0.44	0.18990 (0.00256 to 0.37716)	0.05*	−0.00579 (−0.19164 to 0.18006)	0.95
Inverse Simpson's diversity index	1.01 (0.98 to 1.05)	0.43	0.00099 (−0.00072 to 0.00270)	0.26	−0.00041 (−0.00185 to 0.00104)	0.58
Shannon-Weiner diversity index	1.14 (0.80 to 1.64)	0.47	0.02069 (−0.00717 to 0.04855)	0.15	−0.00179 (−0.02782 to 0.02424)	0.89

CI, confidence interval; OR, odds ratio.

All glaucoma analyses were adjusted for body mass index, use of antibiotics, probiotics, proton-pump inhibitors, lipid-lowering medications and antidiabetics, travelling, and technical covariates (time sample has spent in the mail, the season in which the sample was produced, the number of reads, the DNA isolation batch and the sequencing batch). Intraocular pressure and vertical cup-to-disc ratio analyses were additionally adjusted for age and sex.

^*P value < 0.05.