Table 3.

Meta-Analyzed Associations (Results of Discovery Cohort With Results of TwinsUK and the Study of Health in Pomerania [SHIP]) of Alpha-Diversity With Glaucoma, Intraocular Pressure, and Vertical Cup-to-Disc Ratio

	Glaucoma		Intraocular Pressure		Vertical Cup-to-Disc Ratio
	OR (95% CI)	P Value	Beta (95% CI)	P Value	Beta (95% CI)	P value
Simpson's diversity index	1.61 (0.17 to 15.68)	0.68	0.19648 (0.03288 to 0.36009)	0.02*	–	–
Inverse Simpson's diversity index	–	–	–	–	−0.00011 (−0.00032 to 0.00011)	0.34
Shannon-Weiner diversity index	1.12 (0.80 to 1.56)	0.52	0.02060 (−0.00038 to 0.04157)	0.05	−0.00423 (−0.01422 to 0.00577)	0.41

CI, confidence interval; OR, odds ratio.

Random-effects meta-analyses assessing the association between alpha diversity and glaucoma, intraocular pressure, and vertical cup-to-disc ratio. The analyses from the discovery cohort were adjusted for body mass index (BMI), use of antibiotics, probiotics, proton-pump inhibitors, lipid-lowering medications and antidiabetics, travelling, and technical covariates (time sample has spent in the mail, the season in which the sample was produced, the number of reads, the DNA isolation batch and the sequencing batch). The analyses for intraocular pressure and vertical cup-to-disc ratio were additionally adjusted for age and sex. In TwinsUK, all analyses were adjusted for aforementioned covariates. Data on use of probiotics and travelling was not available. In SHIP, all analyses were adjusted for age, sex, BMI, use of proton-pump inhibitors, lipid-lowering medications and antidiabetics, and the sequencing batch.

^*P value < 0.05.