Table 2.
Neuropathology Burden Showing Ages at Death and Frequencies of End-of-Life Cognitive Impairment
| Cohort and NC Burden | n | Age at Death (mean years) |
Unimpaired n (%) |
Mild/Moderate Impairment n (%) |
Severe Impairment/demented n (%) |
|---|---|---|---|---|---|
| HAAS | |||||
| Negligible neuropathology | 90 | 90 | 52 (58) | 25 (28) | 13 (14) |
| One NC, any type | 120 | 91 | 55 (46) | 33 (28) | 32 (27) |
| Two NC, any combination | 73 | 89 | 24 (33) | 14 (19) | 35 (48) |
| Three or more, any combination | 21 | 92 | 2 (10) | 2 (10) | 17 (81) |
| Totals: | 304 | 133 (44) | 74 (24) | 97 (32) | |
| Nun Study | |||||
| Negligible neuropathology | 162 | 91 | 76 (47) | 64 (39) | 22 (14) |
| One NC, any type | 130 | 91 | 27 (21) | 47 (36) | 56 (43) |
| Two NC, any combination | 58 | 91 | 1 (2) | 20 (33) | 37 (65) |
| Three or more, any combination | 13 | 91 | 0 | 1 (8) | 12 (92) |
| Totals: | 363 | 104 (29) | 132 (36) | 127 (35) | |
| 90+ Study | |||||
| Negligible neuropathology | 102 | 98 | 46 (45) | 36 (35) | 20 (20) |
| One NC, any type | 161 | 98 | 51 (32) | 43 (27) | 67 (41) |
| Two NC, any combination | 87 | 98 | 11 (13) | 16 (18) | 60 (69) |
| Three or more, any combination | 23 | 98 | 2 (9) | 5 (22) | 16 (70) |
| Totals: | 373 | 110 (30) | 100 (27) | 163 (44) | |
Row percentages demonstrate relationship of total neuropathologic burden to final cognitive state.