Table 3.
Relationship of Final Cognitive State to Alzheimer Disease Neuropathologic Change (ADNC) and non-ADNC
| Cohort | n | Negligible NC n (%) |
Pure ADNC n (%) |
ADNC plus 1 non-ADNC n (%) |
ADNC plus >=2 non-ADNC n (%) |
No ADNC 1 non-ADNC n (%) |
No ADNC 2 or more non-ADNC n (%) |
|---|---|---|---|---|---|---|---|
| HAAS | |||||||
| Unimpaired | 133 | 52 (39) | 5 (4) | 5 (4) | 1 (1) | 50 (38) | 20 (15) |
| Mild/Moderate Impairment | 74 | 25 (34) | 1 (1) | 5 (7) | 2 (3) | 32 (43) | 9 (12) |
| Severe Impairment | 97 | 13 (13) | 4 (4) | 12 (12) | 16 (17) | 28 (29) | 24 (25) |
| Nun Study | |||||||
| Unimpaired | 104 | 76 (73) | 6 (6) | 1 (1) | 0 (0) | 21 (20) | 0 (0) |
| Mild/Moderate Impairment | 132 | 64 (48) | 25 (19) | 16 (12) | 1 (1) | 25 (17) | 4 (3) |
| Severe Impairment | 127 | 22 (17) | 35 (28) | 34 (27) | 12 (9) | 21 (17) | 3 (2) |
| 90+ Study | |||||||
| Unimpaired | 110 | 46 (42) | 28 (25) | 11 (10) | 2 (2) | 23 (21) | 0 (0) |
| Mild/Moderate Impairment | 100 | 36 (36) | 24 (24) | 14 (14) | 5 (5) | 19 (19) | 2 (2) |
| Severe Impairment | 163 | 20 (12) | 41 (25) | 56 (35) | 15 (9) | 26 (16) | 5 (3) |
Row percentages demonstrate relationships of final cognitive state with frequencies of single and multiple NC.