Table 4.
End of Life Cognitive Function Categories in Full Cohorts and in Subsets with Negligible Levels of Selected Types of Neuropathologic Change (NC)
| Cohorts and Selected Subsets | Total n |
Unimpaired n (%) |
Mild/ Moderate impairment n (%) |
Moderate/Severe Impairment n (%) |
|---|---|---|---|---|
| HAAS | ||||
| full cohort | 304 | 133 (44) | 74 (24) | 97 (32) |
| subset with negligible ADNC | 253 | 122 (48) | 66 (26) | 65 (26) |
| subset with negligible uVBI NC | 168 | 87 (52) | 42 (25) | 39 (23) |
| subset with negligible neocortical and limbic LBD NC | 259 | 117 (45) | 66 (26) | 76 (29) |
| subset with negligible LATE NC | 226 | 105 (46) | 58 (26) | 63 (28) |
| subset with negligible HS NC | 248 | 117 (47) | 64 (26) | 67 (27) |
| subset with negligible ADNC and uVBI NC | 147 | 80 (54) | 38 (26) | 29 (20) |
| subset with negligible ADNC and Lewy NC | 217 | 107 (49) | 59 (27) | 51 (24) |
| subset with negligible NC, all types | 90 | 52 (58) | 25 (28) | 13 (14) |
| Nun Study | ||||
| full cohort | 363 | 104 (29) | 132 (36) | 127 (35) |
| subset with negligible ADNC | 233 | 97 (42) | 90 (38) | 46 (20) |
| subset with negligible uVBI NC | 315 | 90 (28) | 119 (38) | 106 (34) |
| subset with negligible neocortical and limbic LBD NC | 320 | 97 (30) | 120 (38) | 103 (32) |
| subset with negligible LATE NC | 310 | 104 (34) | 115 (37) | 91 (29) |
| subset with negligible HS NC | 324 | 103 (32) | 120 (37) | 101 (31) |
| subset with negligible ADNC and uVBI NC | 201 | 83 (41) | 80 (40) | 38 (19) |
| subset with negligible ADNC and Lewy NC | 214 | 91 (40) | 84 (39) | 39 (18) |
| subset with negligible NC, all types | 162 | 76 (47) | 64 (39) | 22 (14) |
| 90+ Study | ||||
| full cohort | 373 | 110 (29) | 100 (2) | 163 (44) |
| subset with negligible ADNC | 177 | 69 (39) | 57 (32) | 51 (29) |
| subset with negligible uVBI NC | 355 | 108 (30) | 95 (26) | 152 (43) |
| subset with negligible neocortical and limbic LBD NC | 320 | 100 (31) | 88 (27) | 132 (41) |
| subset with negligible LATE NC | 256 | 90 (35) | 75 (29) | 91 (35) |
| subset with negligible HS NC | 330 | 102 (30) | 94 (28) | 134 (41) |
| subset with negligible ADNC and uVBI NC | 169 | 67 (39) | 56 (33) | 46 (27) |
| subset with negligible ADNC and Lewy NC | 160 | 63 (39) | 52 (32) | 45 (28) |
| subset with negligible NC, all types | 102 | 46 (45) | 36 (35) | 20 (20) |
Row frequencies and percentages show distribution across levels of cognitive impairment