TABLE 4.

Quality of life changes from baseline (continuous positive airway pressure participants)

	Change from baseline		Sex difference
	Females (n=34)	Males (n=81)	Female versus male	p-value
Decrease in scores indicates improvement
ESS	−4.1 (−5.1– −3.0)	−2.5 (−3.1– −1.8)	−1.6 (−2.9– −0.3)	0.015
FSS	−9.1 (−12.3– −6.0)	−5.7 (−7.7– −3.7)	−3.5 (−7.3–0.3)	0.07
HADS Anxiety	−0.7 (−1.6–0.2)	−0.4 (−0.9–0.2)	−0.3 (−1.4–0.7)	0.53
HADS Depression	−1.3 (−2.2– −0.4)	−1.0 (−1.6– −0.4)	−0.3 (−1.4–0.8)	0.58
ISI	−4.9 (−6.2– −3.5)	−3.5 (−4.3– −2.6)	−1.4 (−3.0–0.2)	0.09
Increase in scores indicates improvement
FOSQ	1.8 (1.2–2.3)	1.2 (0.8–1.5)	0.6 (−0.0–1.3)	0.06
EQ-5D Index	0.04 (−0.01–0.08)	0.02 (−0.01–0.05)	0.01 (−0.04–0.07)	0.63
EQ-5D VAS	5.7 (0.8–10.6)	0.5 (−2.8–3.9)	5.2 (−0.8–11.2)	0.09
SF-36 Vitality	9.4 (6.8–12.0)	6.0 (4.3–7.7)	3.4 (0.3–6.5)	0.034
SF-36 Physical	0.6 (−1.2–2.4)	1.1 (−0.0–2.2)	−0.5 (−2.6–1.7)	0.66
SF-36 Mental	4.7 (2.2–7.2)	3.4 (1.9–5.0)	1.3 (−1.7–4.2)	0.40

Data are presented as adjusted mean (95% CI), unless otherwise stated. Sex difference (females−males) is presented as the difference in adjusted mean change from baseline (95% CI). Adjusted means and 95% CIs are from an ANCOVA model of change from baseline, adjusting for sex, baseline score and average daily continuous positive airway pressure usage (h). Missing scores at month 3 were replaced with baseline scores using a last observation carried forward approach. ESS: Epworth Sleepiness Scale; FSS: Fatigue Severity Score; HADS: Hospital Anxiety and Depression Scale; ISI: Insomnia Sleep Index; FOSQ: Functional Outcomes of Sleep Questionnaire; EQ-5D: EuroQol 5 Dimensions Questionnaire; VAS: visual analogue scale; SF-36: 36-item Short-Form Health Survey. p-value for the test of difference between females and males.