Table 1. Demographic and clinical characteristics of patients with PTC diagnosed between 1993 and 2018 and positive for NTRK gene fusion (n = 6).
| Patient 1* | Patient 2* | Patient 3 | Patient 4 | Patient 5 | Patient 6* | |
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Year of thyroid cancer diagnosis | 1993 | 1993 | 2009 | 2009 | 2011 | 2018 |
| Age group at cancer diagnosis (years)† | 50–54 | 55–59 | 40–44 | 30–34 | 25–29 | 55–59 |
| Lifestyle factors/comorbidities | ||||||
| BMI (kg/m2) | N/A | N/A | 22.4 | 25.8 | 22.6 | 22.98 |
| Smoking status | N/A | N/A | Non-smoker | Current smoker | Non-smoker | Non-smoker |
| Comorbidities | N/A | N/A | None | None | None | None |
| CCI at thyroid cancer diagnosis | N/A | N/A | 1 | 0 | 0 | 0 |
| Tumor characteristics | ||||||
| Stage at diagnosis (AJCC) | NA | NA | Unknown | Unknown | I | Unknown |
| Stage at diagnosis (TNM) | NA | NA | T1N0Mx | T1N1Mx | T1N1aM0 | T1bNxMx |
| Genetic characteristics | ||||||
| NTRK gene | NTRK3 | NTRK3 | NTRK3 | NTRK3 | NTRK3 | NTRK3 |
| NTRK gene fusion partner | EML4 | EML4 | EML4 | RBPMS | ETV6 | ETV6 |
| Genomic co-alteration | None | None | None | RB1 deletion | NSG2::KIF5B |
BRAF-V600E
detected in the other lobe |
| Cancer treatments | ||||||
| Radiotherapy | N/A | N/A | No | No | No | No |
| Radioactive iodine ablation (RAI-131) | N/A | N/A | Yes | Yes | Yes | No |
| Time to first treatment (months) | N/A | N/A | 13.5 | 4.0 | 2.6 | N/A |
| Number of treatments | N/A | N/A | 1 | 2 | 2 | N/A |
| Chemotherapy | N/A | N/A | No | No | No | No |
| Observation length (years) | 25.8 | 25.2 | 9.8 | 9.1 | 7.0 | 0.8 |
| Vital status at end of follow-up‡ | Alive | Alive | Alive | Alive | Alive | Alive |
*Patient was diagnosed with PTC outside of the period 1995–2017 and therefore did not have EHR data. These three patients were not included in the subcohort. †According to National Cancer institute Surveillance, Epidemiology, and End Results Program (NCI SEER data) age categorization. ‡Vital status on 30 November 2018. Note: Use of N/A is because these patients did not have EHR data. Abbreviations: AJCC: American Joint Committee on Cancer; BMI: body mass index; N/A: not applicable; NTRK: neurotrophic tyrosine receptor kinase; PTC: papillary thyroid cancer; RB1: RB transcriptional corepressor 1; TNM: tumor-node-metastasis; Mx: metastasis unknown.