Table 3. Characteristics of the 234 patient subcohort diagnosed from 2005–2017 with PTC and with NTRK gene fusion data and linked EHR data.
| Characteristic | NTRK gene fusion N = 3 n (%) | NTRK wild type N = 231 n (%) |
|---|---|---|
| Age at thyroid cancer diagnosis | ||
| Median (IQR) | 31.0 (15.0) | 56.0 (23.0) |
| 18–39 | 2 (66.7) | 51 (22.1) |
| 50–54 | 1 (33.3) | 60 (26.0) |
| ≥55 | 0 (0) | 120 (52.0) |
| Sex | ||
| Female | 1 (33.3) | 173 (74.9) |
| Male | 2 (66.7) | 58 (25.1) |
| BMI, kg/m2 | ||
| <30 (non-obese) | 3 (100.0) | 117 (50.7) |
| ≥30 (obese) | 0 (0.0) | 42 (18.2) |
| Missing | 0 (0.0) | 72 (31.2) |
| Smoking status | ||
| Current | 1 (33.3) | 45 (19.5) |
| Former | 0 (0.00) | 35 (15.15) |
| Never | 2 (66.7) | 117 (50.7) |
| Missing | 0 (0.0) | 34 (14.7) |
| Charlson Comorbidity Index at diagnosis | ||
| Median (IQR) | 0.0 (1.0) | 2.0 (3.0) |
| 0–2 | 3 (100) | 116 (50.2) |
| 3–4 | 0 (0.0) | 81 (35.1) |
| ≥5 | 0 (0.0) | 34 (14.7) |
| Cancer stage at diagnosis, AJCC* | ||
| I | 1 (33.3) | 69 (29.9) |
| II | 0 (0.0) | 9 (3.9) |
| III | 0 (0.0) | 2 (0.9) |
| IV | 0 (0.0) | 2 (0.9) |
| Unknown | 2 (66.7) | 149 (64.5) |
| Cancer treatments | ||
| Radiotherapy | 0 (0.0) | 36 (15.6) |
| Radioactive iodine ablation | 3 (100.0) | 159 (68.8) |
| Chemotherapy | 0 (0.0) | 28 (12.1) |
| Procedures*, median (IQR) | ||
| Total | 46 (29.0) | 33 (39.0) |
| Before PTC diagnosis | 6 (3.0) | 6 (16.0) |
| After PTC diagnosis | 40 (32.0) | 25 (26.0) |
| Hospitalizations (mean number per patient) | ||
| Visit | 215 (71.7) | 16,669 (72.2) |
| Ward | 14 (4.7) | 1447 (6.3) |
| Deaths/survival | ||
| Length of observation while alive (median, IQR) | 9.12 (2.8) | 7.23 (5.3) |
| Total deaths | 0 (0.0) | 32 (13.9) |
| Deaths within 5 years | 0 (0.0) | 16 (6.9) |
| Death within 10 years | 0 (0.0) | 30 (13.0) |
*Included extensive surgical operations, small operations, medical imaging, device-assisted examinations and some therapies. *AJCC stage was derived based on the available TNM data. Unknown classification is due to missing or incomplete TNM. Abbreviations: AJCC: American Joint Committee on Cancer; BMI: body mass index; EHR: electronic health record; IQR: inter-quartile range; NTRK: neurotrophic tyrosine receptor kinase.