Table 2. Toxicity observed during the study, according to the Common Terminology Criteria for Adverse Events (CTCAE) version 3 criteria.

Grade (CTCAE version 3)	Vitamin E				Placebo
	1	2	3	4	1	2	3	4
Diarrhea	5 (14.7%)	5 (14.7%)	0	0	3 (8.8%)	0	1 (2.9%)	0	P = 0.06
Vomiting	6 (17.6%)	2 (5.9%)	0	0	6 (17.6%)	0	0	0	P = 0.38
Nausea	11(32.4%)	4 (11.8%)	0	0	8 (23.5%)	2 (5.9%)	2 (5.9%)	0	P = 0.36
Mucositis	7 (20.6%)	0	0	0	4 (11.8%)	0	0	0	P = 0.38
Fatigue	6 (17.6%)	4 (11.8%)	2 (5.9%)	0	9 (26.5%)	5 (14.7%)	0	0	P = 0.20
Headache	4 (11.8%)	0	0	0	2 (5.9%)	0	0	0	P = 0.45
Vertigo	3 (8.8%)	0	0	0	4 (11.8%)	0	0	0	P = 0.54
Bleeding	1 (2.9%)	0	0	0	1 (2.9%)	0	0	0	P = 0.90