Table 2. Toxicity observed during the study, according to the Common Terminology Criteria for Adverse Events (CTCAE) version 3 criteria.
| Grade (CTCAE version 3) | Vitamin E | Placebo | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | ||
| Diarrhea | 5 (14.7%) | 5 (14.7%) | 0 | 0 | 3 (8.8%) | 0 | 1 (2.9%) | 0 | P = 0.06 | 
| Vomiting | 6 (17.6%) | 2 (5.9%) | 0 | 0 | 6 (17.6%) | 0 | 0 | 0 | P = 0.38 | 
| Nausea | 11(32.4%) | 4 (11.8%) | 0 | 0 | 8 (23.5%) | 2 (5.9%) | 2 (5.9%) | 0 | P = 0.36 | 
| Mucositis | 7 (20.6%) | 0 | 0 | 0 | 4 (11.8%) | 0 | 0 | 0 | P = 0.38 | 
| Fatigue | 6 (17.6%) | 4 (11.8%) | 2 (5.9%) | 0 | 9 (26.5%) | 5 (14.7%) | 0 | 0 | P = 0.20 | 
| Headache | 4 (11.8%) | 0 | 0 | 0 | 2 (5.9%) | 0 | 0 | 0 | P = 0.45 | 
| Vertigo | 3 (8.8%) | 0 | 0 | 0 | 4 (11.8%) | 0 | 0 | 0 | P = 0.54 | 
| Bleeding | 1 (2.9%) | 0 | 0 | 0 | 1 (2.9%) | 0 | 0 | 0 | P = 0.90 |