Table I.
Participant Characteristics, Demographics and Vascular Risk Factors
| All (N = 56) | High PVS Burden (N = 39) | Low PVS Burden (N = 17) | p-value | |
|---|---|---|---|---|
|
| ||||
| Age (Years), M (SD) | 68.2 (6.5) | 68.7 (6.7) | 66.8 (6.1) | .316 |
| Sex (Male), N (%) | 17 (30.4) | 9 (23.1) | 8 (47.1) | .073 |
| Education (Years), M (SD) | 16.2 (2.5) | 16.4 (2.3) | 15.8 (3.0) | .446 |
| Aβ40 (pg/mL), M (SD) | 178.4 (40.0) | 182.3 (40.0) | 169.4 (39.9) | .273 |
| Aβ42 (pg/mL), M (SD) | 9.4 (3.6) | 8.8 (3.6) | 10.5 (3.4) | .097 |
| Aβ42/40, M (SD) | .05 (.02) | .05 (.02) | .06 (.02) | .018 |
| APOE4 Carrier, N (%)1 | 30 (58.8) | 22 (61.1) | 8 (53.3) | .607 |
| Vascular Risk Factors, N (%)2 | ||||
| Hypertension | 19 (34.5) | 13 (33.3) | 6 (37.5) | .768 |
| Dyslipidemia | 23 (41.8) | 18 (46.2) | 5 (31.3) | .309 |
| Diabetes | 5 (9.1) | 2 (5.1) | 3 (18.8) | .110 |
| Smoking History | 20 (36.4) | 13 (33.3) | 7 (43.8) | .466 |
| TIA | 2 (3.6) | 2 (5.1) | 0 (0.0) | .356 |
| Cardiovascular Disease | 8 (14.5) | 8 (20.5) | 0 (0.0) | .050 |
| Left Ventricular Hypertrophy | 2 (3.6) | 2 (5.1) | 0 (0.0) | .356 |
| Atrial Fibrillation | 4 (7.3) | 4 (10.3) | 0 (0.0) | .183 |
| White Matter Hyperintensities3 | 19 (34.5) | 16 (42.1) | 3 (17.6) | .078 |
Note: P-values reported are based on two-tailed t-tests and chi-square tests, not correcting for age.
1
Missing for 2 participants with low PVS and 3 participants with high PVS burden.
2
Missing for 1 participant with low PVS burden.
3
White matter hyperintensities were scored using the Fazekas scale and frequency of scores over 1 is reported; missing for 1 participant with high PVS.