Fig 6. Path analysis in MS patients.

Representations of the multi-layer paths identified from the Boolean simulations when the input started at the cytomics layer. The top paths (those that passed the test for negative controls) are shown for each input (gene, protein, or cell)-output (clinical phenotype) pair. The nodes for each layer are color-coded to represent the degree of a given node, i.e., the number of times the node appears in a path, as a percentage of the total number of paths. High resolution paths are available at https://keithtopher.github.io/fivelayer_pathways/.