TABLE 1.
Selected Characteristics of Patients, Including Selected Emergency Department Interventions, by Adjudication Status for Sepsis-3
| Category | Subcategory | Total, n = 572 | Sepsis-3 | p | |
|---|---|---|---|---|---|
| No, n = 420 | Yes, n = 152 | ||||
| Age | Median (Q1–Q3) | 56.0 (40.0–68.0) | 53.0 (37.0–66.0) | 63.0 (46.0–73.0) | < 0.0001 |
| Subjects ≥ 65. n (%) | 187 (32.7) | 118 (28.1) | 69 (45.4) | < 0.0001 | |
| Biological sex, n (%) | Male | 322 (56.3) | 227 (54.1) | 95 (62.5) | ns |
| Female | 250 (43.7) | 193 (46.0) | 57 (37.5) | ns | |
| Race, n (%) | Black | 172 (30.1) | 130 (31.0) | 42 (27.6) | ns |
| White | 356 (62.2) | 255 (60.7) | 101 (66.5) | ns | |
| Other | 44 (7.7) | 35 (8.3) | 9 (5.9) | ns | |
| Comorbidities, n (%) | Autoimmune Disease | 23 (4.0) | 16 (3.8) | 7 (4.6) | ns |
| Diabetes | 165 (28.9) | 111 (26.4) | 54 (35.5) | < 0.05 | |
| HIV | 11 (1.9) | 5 (1.2) | 6 (4.0) | < 0.05 | |
| Hepatitis C | 46 (8.0) | 32 (7.6) | 14 (9.2) | ns | |
| Hypertension | 290 (50.7) | 200 (47.6) | 90 (59.2) | ns | |
| Obesity | 98 (17.1) | 65 (15.5) | 33 (21.7) | ns | |
| End-stage renal disease | 18 (3.2) | 14 (3.3) | 4 (2.6) | ns | |
| Outpatient medications, n (%) | Antibiotics | 67 (11.7) | 43 (10.2) | 24 (15.8) | ns |
| Anti-inflammatory | 179 (31.3) | 121 (28.8) | 58 (38.2) | < 0.05 | |
| Corticosteroids | 41 (7.2) | 25 (5.6) | 16 (10.5) | ns | |
| Infected by adjudication, n (%) | Yes | 286 (50.0) | 134 (31.9) | 152 (100.0) | < 0.0001 |
| Sepsis adjudication, n (%) | Unanimous | 450 (78.7) | 334 (79.5) | 116 (76.3) | ns |
| Consensus | 120 (21.0) | 84 (20.0) | 36 (23.7) | ns | |
| Forced | 2 (0.4) | 2 (0.5) | 0 (0.0) | ns | |
| Lactate measured, n (%) | Yes | 294 (51.4) | 178 (42.4) | 116 (76.3) | < 0.0001 |
| Lactate, median (Q1–Q3) | 1.7 (1.3–2.6) | 1.6 (1.3–2.6) | 1.8 (1.3–2.7) | ns | |
| IntelliSep Index, median (Q1–Q3) | 5.2 (4.1–6.5) | 4.8 (3.9–5.9) | 6.4 (5.3–7.5) | < 0.0001 | |
ns = not significant, Q1–Q3 = interquartile range.
Cancer refers to those with history or current cancer that did not meet the study exclusion criteria of history of hematologic malignancies, and/or receipt of cytotoxic chemotherapy within 3 months of the emergency department encounter. “Anti-inflammatory” outpatient medications included acetaminophen (Tylenol), celecoxib (Celebrex), ibuprofen (Advil), indomethacin (Indocin), and naproxen (Aleve). S1-Table 1 (http://links.lww.com/CCX/B289) contains the complete table of characteristics.