TABLE 2.
Selected Characteristics of Patients, Including Selected Emergency Department Interventions, by Interpretation Band
| Category | Subcategory | Interpretation Band | p | ||
|---|---|---|---|---|---|
| Band 1, n = 252 | Band 2, n = 160 | Band 3, n = 160 | |||
| Age | Median (Q1–Q3) | 54.0 (39.8–67.0)a,b | 56.0 (39.0–68.0)a,c | 58.00 (41.8–71.0)b,c | nsa, nsb, nsc |
| ≥ 65, n (%) | 77 (30.6)a,b | 54 (33.8)a,c | 56 (35.0)b,c | nsa, nsb, nsc | |
| Biological sex, n (%) | Male | 146 (57.9)a,b | 92 (57.5)a,c | 84 (52.5)b,c | nsa, nsb, nsc |
| Female | 106 (42.1)a,b | 68 (42.5)a,c | 76 (47.5)b,c | nsa, nsb, nsc | |
| Race, n (%) | Black or African American | 76 (30.2)a,b | 47 (29.4)a,c | 49 (30.6)b,c | nsa, nsb, nsc |
| White | 154 (61.1)a,b | 104 (65.0)a,c | 98 (61.3)b,c | nsa, nsb, nsc | |
| Other | 22 (8.7)a,b | 9 (5.6)a,c | 13 (8.1)b,c | nsa, nsb, nsc | |
| Comorbidities, n (%) | Autoimmune disease | 9 (3.6)a,b | 7 (4.4)a,c | 7 (4.4)b,c | nsa, nsb, nsc |
| Diabetes | 71 (28.2)a,b | 40 (25.0)a,c | 54 (33.8)b,c | nsa, nsb, nsc | |
| HIV | 2 (0.8)a,b | 3 (1.9)a,c | 6 (3.8)b,c | nsa, p < 0.05b, nsc | |
| Hepatitis C | 20 (7.9)a,b | 11 (6.9)a,c | 15 (9.4)b,c | nsa, nsb, nsc | |
| Hypertension | 121 (48.0)a,b | 82 (51.3)a,c | 87 (54.4)b,c | nsa, nsb, nsc | |
| Obesity | 44 (17.5)a,b | 32 (20.0)a,c | 22 (13.8)b,c | nsa, nsb, nsc | |
| End-stage renal disease | 6 (2.4)a,b | 9 (5.6)a,c | 3 (1.9)b,c | nsa, nsb, nsc | |
| Outpatient medications, n (%) | Antibiotics | 30 (11.9)a,b | 17 (10.6)a,c | 20 (12.5)b,c | nsa, nsb, nsc |
| Anti-inflammatory | 79 (31.3)a,b | 45 (28.1)a,c | 55 (28.1)b,c | nsa, nsb, nsc | |
| Corticosteroids | 18 (7.1)a,b | 10 (6.3)a,c | 13 (8.1)b,c | nsa, nsb, nsc | |
| Adjudicated sepsis-3 | Yes | 28 (11.1)a,b | 45 (28.1)a,c | 79 (49.4)b,c | p < 0.0001a, p < 0.0001b, p < 0.0001c |
| Sepsis adjudication, n (%) | Unanimous | 206 (81.8)a,b | 120 (75.0)a,c | 124 (77.5)b,c | nsa, nsb, nsc |
| Consensus | 44 (17.5)a,b | 40 (25.0)a,c | 36 (22.5)b,c | nsa, nsb, nsc | |
| Forced | 2 (0.8)a,b | 0 (0.0)a,c | 0 (0.0)b,c | nsa, nsb, nsc | |
| WBC (103 cells/µL), median (Q1–Q3) | 8.9 (6.7–12.9)a,b | 12.6 (9.4–15.7)a,c | 15.7 (11.8–19.1)b,c | p < 0.0001a, p < 0.0001b, p < 0.0001c | |
| Lactate measured, n (%) | Yes | 93 (36.9)a,b | 91 (56.9)a,c | 110 (68.8)b,c | p < 0.0001a, p < 0.0001b, p < 0.05c |
| Lactate, median (Q1–Q3) | 1.6 (1.2–2.6)a,b | 1.6 (1.2–2.7)a,c | 1.8 (1.3–2.6)b,c | nsa, nsb, nsc | |
| IntelliSep Index, median (Q1–Q3) | 4.0 (3.3–4.4)a,b | 5.5 (5.2–5.9)a,c | 7.4 (6.7–7.9)b,c | p < 0.0001a, p < 0.0001b, p < 0.0001c | |
ns = not significant, Q1–Q3 = interquartile range.
Cancer refers to those with history or current cancer that did not meet the study exclusion criteria of history of hematologic malignancies, and/or receipt of cytotoxic chemotherapy within 3 months of the emergency department encounter. “Anti-inflammatory” outpatient medications included acetaminophen (Tylenol), celecoxib (Celebrex), ibuprofen (Advil), indomethacin (Indocin), and naproxen (Aleve). S1-Table 2 (http://links.lww.com/CCX/B289) contains the complete table of characteristics.