Table 2.

Hub Regions in Metabolic Networks for NC, MCI, and AD Groups.^a

Hemisphere	Brodmann Areas	Brain Regions	Normalized Betweenness
			NC	MCI	AD
Left	Area 8	Frontal eye fields	3.352	2.297	0.706
	Area 7	Somatosensory association cortex	2.596	0.246	0.554
	Area 5	Somatosensory association cortex	2.526	0.600	0.249
	Area 4	Primary motor cortex	2.436	2.237	0.395
	Area 29	Retrosplenial cingulate cortex	2.370	1.143	0.608
	Area 32	Dorsal anterior cingulate cortex	1.001	0.591	5.362
	Area 47	Inferior prefrontal gyrus	0.446	3.693	0.044
	Area 26	Ectosplenial area	0.410	2.550	0.535
	Area 35	Perirhinal cortex	0.358	2.193	0.100
	Area 27	Piriform cortex	0.326	2.976	0.362
	Area 20	Inferior temporal gyrus	0.249	0.325	5.702
	Areas 3, 1, and 2	Primary somatosensory cortex	0.172	0.276	4.565
Right	Area 48	Retrosubicular area	3.615	2.583	0.134
	Area 25	Subgenual cortex	3.233	1.227	0.623
	Area 30	Part of cingulate cortex	3.082	1.358	0.407
	Areas 3, 1, and 2	Primary somatosensory cortex	2.696	0.221	0.920
	Area 5	Somatosensory association cortex	2.684	0.775	0.104
	Area 34	Anterior entorhinal cortex	2.469	0.488	0.181
	Area 8	Includes frontal eye fields	2.448	0.489	0.574
	Areas 3, 1, and 2	Primary somatosensory cortex	2.139	1.180	0.173
	Area 11	Orbitofrontal area	1.817	3.083	4.302
	Area 40	Wernicke’s area	1.057	0.100	5.792
	Area 32	Dorsal anterior cingulate cortex	0.963	0.745	2.547
	Area 47	Inferior prefrontal gyrus	0.923	2.206	0.159
	Area 44	Broca’s area	0.780	2.327	0.360
	Area 45	Pars triangularis Broca’s area	0.493	3.800	0.004

Abbreviation: AD, Alzheimer’s disease; MCI, mild cognitive impairment; NC, normal control.

^aThe hub regions in the metabolic network of the NC group were listed in a descending order of their normalized betweenness in left brain and then in the right brain.