Table 1.
Demographic, Clinical, and Caregiver Characteristics of Patients With EAOD and LOAD.
| Characteristics | EOAD (n = 35) | LOAD (n = 35) | P Value |
|---|---|---|---|
| Age, in years, mean (SD) | 64.5 (6.5) | 76.0 (3.5) | <.001 |
| Male, n (%) | 25 (71.4) | 25 (71.4) | >.999 |
| Education, in years, median (max-min) | 4 (17-0) | 3 (12-0) | .032 |
| Handedness, right-handed, n (%) | 35 (100) | 35 (100) | |
| Disease duration, mean (SD), years | 5.7 (2.3) | 4.0 (1.5) | .001 |
| Positive family history of dementia, n (%) | 12 (34.3) | 10 (28.6) | .607 |
| MMSE total score, mean (SD) | 16.2 (8.1) | 16.8 (6.0) | .737 |
| NPI total score, mean (SD) | 80.1 (77.0) | 76.4 (81.8) | .702 |
| Psychoactive medication, n (%) | 27 (77.1) | 24 (68.6) | .420 |
| Antipsychotics | 7 (20) | 5 (14.3) | |
| Antidepressants | 20 (57.1) | 17 (48.6) | |
| Benzodiazepines | 19 (54.3) | 6 (17.1) | |
| AD-specific medication (%) | 25 (71.4) | 27 (77.1) | .584 |
| Acetylcholinesterase inhibitors | 17 (48.6) | 24 (68.5) | |
| NMDA receptor antagonists | 13 (37.1) | 7 (20) | |
| GDS score, n (%) | .794 | ||
| Mild (4) | 24 (68.6) | 25 (71.4) | |
| Moderate (5)–severe (6-7) | 11 (31.4) | 10 (28.6) | |
| Caregiver characteristics | |||
| Caregiver sex: men, n (%) | 18 (51.4) | 11 (31.4) | .089 |
| Relationship with patient, n (%) | |||
| Spouse | 21 (60) | 17 (48.6) | |
| Child | 6 (17.1) | 12 (34.3) | |
| Friend | 1 (2.9) | 1 (2.9) | |
| Cohabitating, n (%) | 23 (65.7) | 21 (60) | .621 |
Abbreviations: AD, Alzheimer’s disease; EOAD, early onset AD; GDS, Global Deterioration Scale; LOAD, late onset AD; MMSE, Mini-Mental State Examination; NPI, Neuropsychiatric Inventory; NMDA, N-methyl-D-aspartate; SD, standard deviation.