TABLE 1.
Known GSL receptors for Stx and Shiga-like toxinsa
GSL family | Name (symbol) | GSL structureb |
---|---|---|
gala | Galabiosylceramide | Galα1→4Galβ1→1′Cer |
globo | Globotriaosylceramide (Gb3, CTH, CD77, Pk) | Galα1→4Galβ1→4Glcβ1→1′Cer |
neolacto | IV4-α-Galactosylneolactotetraglycosylceramide (P1) | Galα1→4Galβ1→4GlcNAcβ1→3Galβ1→4Glcβ1→1′Cer |
globoc | Globotetraosylceramide (Gb4,P) | GalNAcβ1→3Galα1→4Galβ1→4Glcβ1→1′Cer |
GSL classification, trivial names, and structures as recommended by the International Union of Pure and Applied Chemistry-International Union of Biology Commission on Biochemical Nomenclature (47).
Underlined oligosaccharides represent the critical terminal Galα1-4Gal disaccharide required for Stx, Stx1, and Stx2 recognition and binding.
Receptor for Stx2e.