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. 2023 Sep 12;116(2):299–308. doi: 10.1093/jnci/djad186

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Figure 1. — Clinical characteristics of early-onset (age <50 years, n = 219) and average-onset (age ≥50 years, n = 904) esophagogastric cancer. A) Comparison of the clinical and pathologic characteristics demonstrates a higher percentage of gastric primary tumor site (64% vs 44%, P < .0001), proportion of women (39% vs 28%, P = .002), Asian race (16% vs 9%, P = .002), and signet ring histology or Lauren diffuse type cancer (31% vs 9%, P < .001) in the early-onset group. B) Histologic subtype distribution in the average-onset group compared with the early-onset group demonstrates a higher proportion of signet ring cell and/or diffuse type in the early-onset gastric cancer than in the average-onset gastric cancer group. C) Presenting symptoms that occurred statistically significantly more frequently in the early-onset group included pain and change in bowel habits, while weight loss and swallowing difficulty occurred more frequently in the average-onset group. BMI = body mass index; GEJ = gastroesophageal junction; GI = gastrointestinal.