Table 1.
Selected Demographic and Clinical Characteristics of Patients According to MMSE Score at 6 Months of Evaluation.
| Quantitative variables | MMSE < 20 | MMSE > 20 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nonresponders | Responders | P | Nonresponders | Responders | P | ||||||||||
| N | Mean | SD | N | Mean | SD | N | Mean | SD | N | Mean | SD | ||||
| Age, years | 25 | 82.960 | 7.191 | 60 | 80.267 | 6.994 | .112 | 39 | 79.795 | 6.856 | 53 | 79.887 | 5.999 | .946 | |
| Education, years | 24 | 3.292 | 2.053 | 60 | 3.600 | 2.763 | .623 | 39 | 4.205 | 2.597 | 53 | 5.623 | 4.161 | .064 | |
| Concomitant diseases | 24 | 2.375 | 1.439 | 58 | 2.707 | 1.214 | .290 | 38 | 2.789 | 1.189 | 52 | 2.692 | 1.292 | .716 | |
| Concomitant therapies, number of drugs | 23 | 3.913 | 3.014 | 57 | 4.614 | 2.343 | .269 | 37 | 4.324 | 2.286 | 51 | 4.353 | 2.726 | .959 | |
| Years of AD | 25 | 6.240 | 2.818 | 59 | 5.593 | 2.614 | .314 | 39 | 6.026 | 2.323 | 53 | 5.226 | 2.407 | .114 | |
| MMSE score at baseline | 25 | 15.400 | 2.828 | 60 | 15.167 | 3.179 | .751 | 39 | 23.051 | 2.695 | 53 | 23.000 | 2.139 | .919 | |
| MMSE scores after 6 months of treatment | 25 | 12.880 | 2.774 | 60 | 17.950 | 4.127 | <.001 | 39 | 20.051 | 2.883 | 53 | 24.226 | 2.318 | <.001 | |
| MMSE scores after 12 months of treatment | 20 | 13.250 | 4.315 | 56 | 17.036 | 4.584 | .002 | 38 | 20.763 | 3.132 | 50 | 23.860 | 3.169 | <.001 | |
| IADL | 21 | 14.095 | 3.897 | 55 | 15.309 | 5.480 | .357 | 34 | 17.912 | 5.276 | 48 | 18.896 | 5.058 | .396 | |
| ADL | 22 | 4.636 | 1.364 | 57 | 4.491 | 1.754 | .698 | 32 | 5.094 | 1.445 | 49 | 5.347 | 1.071 | .368 | |
| Qualitative variables | Nonresponders | Responders | P* | Nonresponders | Responders | P* | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex, n (%) | F—21 (84.0%) | F—50 (83.3%) | .940 | F—28 (71.8%) | F—31 (58.5%) | .189 | |||||||||
| M—4 (16.0%) | M—10 (16.7%) | M—11 (28.3%) | M—22 (41.5%) | ||||||||||||
| BPSD presence, n (%) | No 2 (9.1%) | No 7 (13.7%) | .580 | No 13 (36.1%) | No 11 (21.2%) | .121 | |||||||||
| Yes 20 (90.9%) | Yes 44 (86.3%) | Yes 23 (63.9%) | Yes 41 (78.8%) | ||||||||||||
Abbreviations: n, number of individuals; BPSD, behavioral and psychological symptoms of dementia; MMSE, Mini-Mental State Examination; IADL, Instrumental Activities of Daily Living; ADL, Activities of Daily Living; SD, standard deviation; AD, Alzheimer’s disease; P, P value obtained by Student’s t test; P*, P value obtained by chi-square test; F, female; M, male.