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. 2012 Dec 26;28(2):154–164. doi: 10.1177/1533317512470207

Table 3.

The FA Values Comparison Among Patients With PD With Different Cognitive Status (Mean ± SD).a

Control(n = 21) PD-CogNL (n = 24) PD-MCI (n = 30) PD-D (n = 10) ANOVA, P Value Logistic Regression Analysis
PD-MCI/PD-CogNL PDD/PD-CogNL
Frontal white matter
 Left 0.519 ± 0.096 0.485 ± 0.040 0.463 ± 0.074b 0.446 ± 0.047c .017 NA NA
 Right 0.486 ± 0.076 0.468 ± 0.115 0.465 ± 0.069 0.466 ± 0.478 NS NA NA
Parietal white matter
 Left 0.467 ± 0.095 0.449 ± 0.094 0.454 ± 0.068 0.442 ± 0.036 NS NA NA
 Right 0.463 ± 0.060 0.433 ± 0.039 0.450 ± 0.051 0.424 ± 0.066 NS NA NA
Temporal white matter
 Left 0.503 ± 0.061 0.474 ± 0.039 0.467 ± 0.059 0.476 ± 0.049 NS NA NA
 Right 0.507 ± 0.059 0.483 ± 0.050 0.451 ± 0.052 b,d 0.457 ± 0.052c .003 NS NA
Occipital white matter
 Left 0.433 ± 0.560 0.486 ± 0.087e 0.459 ± 0.074 0.414 ± 0.081f .034 NA NS
 Right 0.482 ± 0.043 0.469 ± 0.083 0.448 ± 0.065 0.449 ± 0.066 NS NA NA
Anterior cingulate bundle
 Left 0.532 ± 0.096 0.470 ± 0.071e 0.454 ± 0.079d 0.384 ± 0.071 c,f,g .000 NA 0.049
 Right 0.438 ± 0.713 0.425 ± 0.066 0.398 ± 0.064a 0.378 ± 0.046b .039 NA NA
Posterior cingulate bundle
 Left 0.440 ± 0.046 0.456 ± 0.063 0.427 ± 0.048 0.437 ± 0.056 NS NA NA
 Right 0.489 ± 0.070 0.469 ± 0.104 0.462 ± 0.075 0.409 ± 0.069 NS NA NA
Splenium of the corpus callosum 0.798 ± 0.051 0.760 ± 0.069 0.765 ± 0.075 0.687 ± 0.121c,f,g .004 NA NS
Genu of the corpus callosum 0.716 ± 0.063 0.727 ± 0.086 0.667 ± 0.098 0.696 ± 0.066 NS NA NA
Corticospinal tract in midbrain
 Left 0.715 ± 0.069 0.714 ± 0.043 0.697 ± 0.041 0.709 ± 0.064 NS NA NA
 Right 0.706 ± 0.071 0.712 ± 0.049 0.729 ± 0.064 0.722 ± 0.062 NS NA NA
Corticospinal tract in internal capsule
 Left 0.631 ± 0.044 0.930 ± 0.047 0.632 ± 0.061 0.637 ± 0.054 NS NA NA
 Right 0.627 ± 0.066 0.940 ± 0.015 0.629 ± 0.064 0.656 ± 0.056 NS NA NA
Superior longitudinal fasciculus
 Left 0.620 ± 0.065 0.629 ± 0.059 0.625 ± 0.070 0.643 ± 0.041 NS NA NA
 Right 0.644 ± 0.045 0.637 ± 0.066 0.622 ± 0.074 0.649 ± 0.050 NS NA NA

Abbreviations: NA, not applicable; NS, nonsignificant; FA, fractional anisotropy; PD-CogNL, Parkinson’s disease with normal cognitive function; PD-MCI, Parkinson’s disease with mild cognitive impairment; PD-D, Parkinson’s disease with dementia; ANOVA, analysis of variance; SD, standard deviation; UPDRS, Unified Parkinson’s Disease Rating Scale.

a Post hoc logistic regression analysis was undertaken to account for baseline differences in UPDRS/Hoehn-Yahr scores. P >.05 was considered nonsignificant.

b Significant FA reductions in PD-MCI compared to controls.

c Significant FA reductions in PD-D compared to controls.

d significant FA reductions in PD-MCI compared to PD-CogNL.

e Significant fractional anisotropy reductions in PD-CogNL compared to controls.

f Significant FA reductions in PD-D compared to PD-CogNL.

g significant FA reductions in PD-D compared to PD-MCI.