Table 1.
Allele and Genotype distribution of PON1 (rs662 and rs854560) Genes Among AD, VaD, and HC Groups.
| Polymorphisms | AD (n = 75) | VaD (n = 46) | HC (n = 120) | P value | OR (95% CI) |
|---|---|---|---|---|---|
| rs662 | |||||
| Alleles | |||||
| Q (wild) | 100 (66.7%) | 49 (53.2%) | 173 (72.1%) | .26a | 1.29 (0.81-2.05)a |
| R (variant) | 50 (33.3%) | 43 (46.8%) | 67 (27.9%) | .001b | 2.27 (1.33-3.83)b |
| Genotypes | |||||
| QQ (wild) | 32 (42.7%) | 14 (30.4%) | 69 (57.5%) | ||
| QR (heterozygous) | 36 (48.0%) | 21 (45.7%) | 35 (29.2%) | .044a | 1.82 (0.97-3.40)a |
| RR (variant) | 7 (9.3%) | 11 (23.9%) | 16 (13.3%) | .002b | 3.09 (1.42-6.91)b |
| rs854560 | |||||
| Alleles | |||||
| L (wild) | 121 (80.7%) | 72 (78.2%) | 192 (80.0%) | .87a | 0.96 (055-1.65)a |
| M (variant) | 29 (19.3%) | 20 (21.8%) | 48 (20.0%) | .72b | 1.11 (0.58-2.06)b |
| Genotypes | |||||
| LL (wild) | 50 (66.7%) | 31 (67.3%) | 76 (63.4%) | ||
| LM (heterozygous) | 21 (28.0%) | 10 (21.8%) | 40 (33.3%) | .64a | 0.86 (0.45-1.65)a |
| MM (variant) | 4 (5.3%) | 5 (10.9%) | 4 (3.3%) | .62b | 0.83 (0.38-1.80)b |
Abbreviations: AD, Alzheimer’s disease; CI, confidence interval; OR, odds ratio; PON1, paraoxonase 1; VaD, vascular dementia; HC, healthy control.
a P value for AD versus HC.
b P value for VaD versus HC.